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Your search for “Drug Discovery” returned 413 results

Drug Discovery Potential of Natural Microbial Genomes

January 22, 2014

Scientists at the University of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound. Their study, published this week in PNAS, may open new avenues for natural product discoveries and drug development.

Roche Funds Drug Discovery Projects at UC San Diego

January 9, 2012

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine.

Artificial Intelligence Aids Discovery of Super Tight-Binding Antibodies

January 31, 2023

UC San Diego scientists developed an artificial intelligence tool that could accelerate the development of new high affinity antibody drugs.

Cancer Drug and Antidepressants Provide Clues for Treating Fatal Brain-Eating Amoeba Infections

September 13, 2018

…identified three new molecular drug targets in Naegleria fowleri and a number of drugs that are able to inhibit the amoeba’s growth in a laboratory dish. Several of these drugs are already approved by the U.S. Food and Drug Administration for other uses, such as antifungal agents, the breast cancer…

UC San Diego Chemists Take Aim at Drug Predictions

June 27, 2019

UC San Diego chemists offer new system to ease the synthesis and evaluation of the algorithms, the chemistry and the technology needed to predict the bound poses of ligands within a targeted protein—a necessity for designing new drugs.

New Way to Target – And Kill – Proliferating Tumors

November 14, 2011

…have identified a new drug discovery approach enabling the destruction of the most highly proliferative tumors. The discovery, published in the November 13 online issue of the journal Nature Medicine, points to an effective, alternative method for killing fast-growing cancer cells without causing some of the negative effects of current…

Cancer Stem Cells Linked to Drug Resistance

April 20, 2014

Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a biomarker called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing…

Discovery Provides Blueprint for New Drugs That Can Inhibit Hepatitis C Virus

March 19, 2012

Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing. Hepatitis C is a chronic infectious disease that affects some 170 million people worldwide and causes…

Pharmaceutical Companies to Share Data for Drug Design via New UC San Diego-Led Resource

October 9, 2014

…unreleased proprietary data for drug discovery through a new $3.7 million effort funded by the National Institutes for Health. The project, which is led by UC San Diego principal investigators Rommie Amaro, Victoria Feher and Dr. Michael K. Gilson, includes a major subcontract to Rutgers University, directed by Dr. Stephen…

New Understanding of ‘Copper Pump’ in Cells Could Prime Discovery of Anti-Cancer Drugs

May 16, 2012

A team of University of California, San Diego researchers has made new discoveries about a copper-transporting protein in the membranes of human cells that drug-discovery scientists can co-opt for the development of new anti-cancer drugs.

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