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Your search for “Dementia” returned 123 results

First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease

February 18, 2021

UC San Diego researchers have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease or Mild Cognitive Impairment, a condition that often precedes full-blown dementia.

Current Screening Methods Miss Worrisome Number of Persons with Mild Cognitive Impairment

May 23, 2016

In a paper published in the current Journal of Alzheimer’s Disease, researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System say existing screening tools for mild cognitive impairment (MCI) result in a false-negative error rate of more than 7 percent. These persons…

Novel Approaches to Treating Alzheimer’s Disease Include Early Intervention

May 15, 2012

Researchers at the Comprehensive Alzheimer’s Program at the University of California, San Diego School of Medicine have announced two new clinical trials for patients with either mild to moderate Alzheimer’s disease (AD) and one trial for Mild Cognitive Impairment.

UC San Diego Launches Unprecedented Down Syndrome Study

December 16, 2013

Down syndrome (DS) is a childhood condition but improved health care means that individuals with DS now routinely reach age 50 or 60 years of age, sometimes beyond. However, if they live long enough, people with Down syndrome are almost certain to develop Alzheimer’s disease.

Newly Evolved, Uniquely Human Gene Variants Protect Older Adults from Cognitive Decline

November 30, 2015

Many human gene variants have evolved specifically to protect older adults against neurodegenerative and cardiovascular diseases, thus preserving their contributions to society, report University of California, San Diego School of Medicine researchers in the November 30 issue of Proceedings of the National Academy of Sciences.

Genetics Overlap Found Between Alzheimer’s Disease and Cardiovascular Risk Factors

April 16, 2015

An international team of scientists, led by researchers at University of California, San Diego School of Medicine, have found genetic overlap between Alzheimer’s disease (AD) and two significant cardiovascular disease risk factors: high levels of inflammatory C-reactive protein (CRP) and plasma lipids or fats. The findings suggest the two cardiovascular…

Increase in Physical Activity Lags Despite Calls to Step it Up During the 2012 Olympics

July 27, 2016

Ahead of the Summer Olympic Games in London four years ago, researchers reported that physical inactivity was a global pandemic that required urgent action. With the 2016 Games looming, University of California San Diego School of Medicine investigators report little change in activity levels worldwide.

Brain Function Boosted by Daily Physical Activity in Middle-Aged, Older Adults

January 31, 2022

Remote UC San Diego School of Medicine study finds brain function boosted by daily exercise in middle-aged and older adults.

Assessing Elderly Drivers: Doctors and Law Enforcement Receive Training

November 3, 2014

Every day in America roughly 10,000 people turn age 65. To help keep roadways safe as America grays and to help preserve the freedom of mobility of older drivers, researchers at University of California, San Diego School of Medicine are training law enforcement officers to recognize warning signs of impaired…

Novel Approach Blocks Amyloid Production in Alzheimer’s Mouse Model

April 29, 2015

Offering a potential early intervention for Alzheimer’s disease (AD), researchers at University of California, San Diego School of Medicine and Cenna Biosciences, Inc. have identified compounds that block the production of beta amyloid peptides in mice. The study is reported April 29 in PLOS ONE.

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