July 27, 2017
…electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that helps pack six feet of DNA into each cell nucleus, construct chromosomes and control gene expression and DNA replication.
February 8, 2018
…at the root of cell formation. They found that DNA executes an unexpected architectural role in shaping the cells of bacteria. Studying the bacterium Bacillus subtilis, the researchers used an array of experiments and technologies to reveal that DNA, beyond serving to encode genetic information, also “pumps up” bacterial cells.
September 12, 2016
A team led by researchers at the University of California San Diego has captured in step-by-step atomic detail the surgical editing of DNA strands by CRISPR-Cas9, the innovative gene-splicing technology that in recent years has transformed the field of genetic engineering.
July 3, 2012
…usually implicated in cancer and in fetal development, called DNA methylation, in the progression of rheumatoid arthritis (RA). They found that epigenetic changes due to methylation play a key role in altering genes that could potentially contribute to inflammation and joint damage.
December 19, 2013
Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.
June 27, 2017
…and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.
October 31, 2016
UC San Diego’s Computer Science and Engineering department and Illumina Inc. co-sponsored DNA Day 2016, a day-long workshop featuring talks and cutting-edge bioinformatics and genomics research, including several speakers with dual appointments in CSE and the UC San Diego School of Medicine.
February 18, 2015
…code. Yet different types of cells read the same DNA in widely different ways, influenced by chemical chemical tags that modify the genetic material without changing the underlying DNA sequence. Scientists today announced significant progress in the unraveling of the code that guides those differences, a body of information they…
November 20, 2019
UC San Diego researchers describe how circular extrachromosomal DNA in cancer cells boosts aggressiveness and resistance to therapies.
November 12, 2021
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
