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Your search for “DNA” returned 589 results

New 3D Imaging Reveals How Human Cell Nucleus Organizes DNA and Chromatin of its Genome

July 27, 2017

…electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that helps pack six feet of DNA into each cell nucleus, construct chromosomes and control gene expression and DNA replication.

Surprise Finding Points to DNA’s Role in Shaping Cells

February 8, 2018

…at the root of cell formation. They found that DNA executes an unexpected architectural role in shaping the cells of bacteria. Studying the bacterium Bacillus subtilis, the researchers used an array of experiments and technologies to reveal that DNA, beyond serving to encode genetic information, also “pumps up” bacterial cells.

SDSC Supercomputer Modeling Reveals Acrobatics of CRISPR-Cas9 Technology

September 12, 2016

A team led by researchers at the University of California San Diego has captured in step-by-step atomic detail the surgical editing of DNA strands by CRISPR-Cas9, the innovative gene-splicing technology that in recent years has transformed the field of genetic engineering.

Epigenetics Alters Genes in Rheumatoid Arthritis

July 3, 2012

…usually implicated in cancer and in fetal development, called DNA methylation, in the progression of rheumatoid arthritis (RA). They found that epigenetic changes due to methylation play a key role in altering genes that could potentially contribute to inflammation and joint damage.

How Cells Remodel After UV Radiation

December 19, 2013

Researchers at the University of California, San Diego School of Medicine, with colleagues in The Netherlands and United Kingdom, have produced the first map detailing the network of genetic interactions underlying the cellular response to ultraviolet (UV) radiation.

Harnessing Cancer’s Methylation Footprint for More Precise Diagnosis and Prognosis

June 27, 2017

…and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.

DNA Day Features UC San Diego Faculty, Alumni Speakers

October 31, 2016

UC San Diego’s Computer Science and Engineering department and Illumina Inc. co-sponsored DNA Day 2016, a day-long workshop featuring talks and cutting-edge bioinformatics and genomics research, including several speakers with dual appointments in CSE and the UC San Diego School of Medicine.

Computational Strategy Helps to Map Human Epigenome

February 18, 2015

…code. Yet different types of cells read the same DNA in widely different ways, influenced by chemical chemical tags that modify the genetic material without changing the underlying DNA sequence. Scientists today announced significant progress in the unraveling of the code that guides those differences, a body of information they…

Artificial Intelligence Catalyzes Gene Activation Research and Uncovers Rare DNA Sequences

May 18, 2023

Biologists have used machine learning, a type of AI, to identify “synthetic extreme” DNA sequences with specifically designed functions in gene activation. They tested 50 million DNA sequences and found synthetic DNA sequences with activities that could be useful in biotechnology and medicine.

Vicious Circles: Ring-shaped DNA Provides Cancer Cells with a Malignant Twist

November 20, 2019

UC San Diego researchers describe how circular extrachromosomal DNA in cancer cells boosts aggressiveness and resistance to therapies.

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