May 2, 2016
When does DNA behave like sand or toothpaste? When the genetic material is so densely packed within a virus, it can behave like grains of sand or toothpaste in a tube. That’s essentially what biophysicists at UC San Diego discovered when they began closely examining the physical properties of DNA…
January 30, 2014
In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important consequences for the body’s cellular response to chemotherapy.
June 25, 2020
Researchers from Harvard University and the University of Texas Medical Branch at Galveston recently used the Comet supercomputer at the San Diego Supercomputer Center at the University of California San Diego to uncover the novel ways in which DNA prepares itself for repair.
February 24, 2017
…new tool to identify RNA-DNA interactions. The tool can provide a full account of all the RNA molecules that interact with a segment of DNA, as well as the locations of all these interactions — in just a single experiment. The research is a step toward identifying new functions and…
June 14, 2016
…an electrical graphene chip capable of detecting mutations in DNA. Researchers say the technology could one day be used in various medical applications such as blood-based tests for early cancer screening, monitoring disease biomarkers and real-time detection of viral and microbial sequences.
May 18, 2023
Biologists have used machine learning, a type of AI, to identify “synthetic extreme” DNA sequences with specifically designed functions in gene activation. They tested 50 million DNA sequences and found synthetic DNA sequences with activities that could be useful in biotechnology and medicine.
May 26, 2014
…out. Researchers at UC San Diego have found that DNA packs more easily into the tight confines of a virus when given a chance to relax.
February 8, 2018
…at the root of cell formation. They found that DNA executes an unexpected architectural role in shaping the cells of bacteria. Studying the bacterium Bacillus subtilis, the researchers used an array of experiments and technologies to reveal that DNA, beyond serving to encode genetic information, also “pumps up” bacterial cells.
December 22, 2011
In eukaryotes – the group of organisms that include humans – a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.
July 27, 2017
…electron microscopic imaging tools and a selective stain for DNA to visualize the three-dimensional structure of chromatin — a complex of molecules that helps pack six feet of DNA into each cell nucleus, construct chromosomes and control gene expression and DNA replication.