October 14, 2013
Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called “master regulators” read the genome, and consequently turn genes on and off.
September 17, 2012
…pathologists and geneticists pledges to “sequence” or analyze the DNA of large numbers of patients with cancer in order to match each patient to the best available drug for his or her particular tumor.
July 21, 2016
…number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. The study, published July 21 in Molecular Cell, uncovered 172…
October 2, 2016
…all human cancers have mutations in a gene called KRAS. KRAS-mutant cancers are among the most difficult to treat, with poor survival and resistance to chemotherapy. Researchers at University of California San Diego School of Medicine and Moores Cancer Center used microRNAs to systematically inhibit thousands of other genes to…
February 6, 2020
Researchers from University of California San Diego School of Medicine have defined the most detailed list of genetic fingerprints of DNA-damaging processes that drive cancer development to date.
September 26, 2022
UC San Diego researchers have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. The work could help identify what environmental factors, such as exposure to tobacco smoke and UV radiation, cause cancer in certain patients.
December 5, 2013
…cancer cells resist therapy by dialing down the gene mutation targeted by drugs, then re-amplify that growth-promoting mutation after therapy has stopped.
August 26, 2020
Molecules known as tRNAs are often overlooked in study of disease processes. Researchers have now found that a mutation in a tRNA gene called n-Tr20—expressed only in the brain—can disrupt the landscape of entire cells, leading to chain reactions that alter brain function and behavior.
August 18, 2017
…a high frequency of gastrointestinal stromal tumors (GISTs) with mutations of the NF1 gene.
December 23, 2020
UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as “chromothripsis” breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.
