December 22, 2011
In eukaryotes – the group of organisms that include humans – a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.
August 3, 2014
Although mutations in a gene dubbed “the guardian of the genome” are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large…
August 4, 2022
UC San Diego and Salk Institute researchers report a surprising link between mitochondria, inflammation and gene mutations that may increase risk of atherosclerosis.
August 22, 2018
In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain and Finland, describe for the first time how one type of RNA polymerase gets stalled by DNA lesions caused by exposure to ultraviolet (UV) light.
September 12, 2017
…determine whether certain hard-to-study mutations in the human genome, called short tandem repeats or microsatellites, are likely to be involved in harmful conditions. The team, which also includes scientists from the New York Genome Center, Harvard University, and the Massachusetts Institute of Technology, details their findings in the Sept. 11…
February 27, 2018
…human metabolism. Researchers used the tool to map disease-related mutations on proteins and also probed how genes and proteins change in response to certain drugs. The work provides a better understanding of disease-causing mutations and could enable researchers to discover new uses for existing drug treatments.
September 12, 2016
A team led by researchers at the University of California San Diego has captured in step-by-step atomic detail the surgical editing of DNA strands by CRISPR-Cas9, the innovative gene-splicing technology that in recent years has transformed the field of genetic engineering.
June 25, 2012
…the Howard Hughes Medical Institute, say de novo somatic mutations in a trio of genes that help regulate cell size and proliferation are likely culprits for causing hemimegalencephaly, though perhaps not the only ones.
October 31, 2016
UC San Diego’s Computer Science and Engineering department and Illumina Inc. co-sponsored DNA Day 2016, a day-long workshop featuring talks and cutting-edge bioinformatics and genomics research, including several speakers with dual appointments in CSE and the UC San Diego School of Medicine.
March 6, 2020
A team of chemists and biochemists at UC San Diego used a combination of computational simulations and experiments to deepen understanding of the latest genome editing technology.
