June 4, 2024
A group of researchers at University of California San Diego has identified the cause of a “short-circuit” in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development of a wide array of new drugs.
June 26, 2015
Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.
January 30, 2014
In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important consequences for the body’s cellular response to chemotherapy.
July 2, 2014
Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression – the process of cell division and replication – activates a key tumor suppressor, rather than inactivating it as previously thought.
November 6, 2017
…how animals respond to infections have found a new pathway that may help in tolerating stressors that damage proteins. Naming the pathway the Intracellular Pathogen Response, or “IPR,” the scientists say it is a newly discovered way for animals to cope with certain types of stress and attacks, including heat…
February 8, 2024
Each cell features mtDNA, instructions that mitochondria use to create energy. When mtDNA remains where it belongs, cells remain healthy. But when it goes where it doesn’t belong, mtDNA can initiate an immune response and inflammation. Scientists have discovered the pathways behind this process.
April 24, 2019
University of California San Diego School of Medicine researchers and collaborators describe a new set of “rules” that predict how the tissue of origin influences critical aspects of the genetic makeup of tumors, with potentially important therapeutic implications.
March 25, 2015
…control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
March 13, 2024
The cells of the human heart form communities and those communities have a surprisingly sophisticated form of biochemical communication necessary for healthy heart development.
December 5, 2018
University of California San Diego School of Medicine researchers engineered sensors to detect and measure the metastatic potential of single cancer cells. Metastasis is attributed as the leading cause of death in people with cancer.
