May 2, 2017
Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin — the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes. Using single-cell RNA sequencing, researchers at University of California San Diego School…
April 2, 2015
Cells of the intestine, liver and pancreas are difficult to produce from stem cells. Writing in Cell Stem Cell April 2, researchers at University of California, San Diego School of Medicine have discovered that chromosomes in laboratory stem cells open slowly over time, in the same sequence that occurs during…
December 11, 2017
Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered…
April 12, 2022
How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? UC San Diego researchers developed a single-cell atlas of postnatal lung development that could help answer these questions.
September 9, 2021
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
November 2, 2018
…the National Institutes of Health to build 3D, digital single-cell maps of the human brain and organs in the respiratory and urinary systems. The work aims to provide a deeper understanding of the functions and malfunctions of organs in the human body at the level of individual cells.
April 13, 2017
Chinese hamster ovary (CHO) cells are the workhorses behind more than half of the top-selling biologics on the market today. Humira, Avastin and Rituxan are a few. Researchers at the UC San Diego CHO Systems Biology Center are developing new tools, such as genome-scale metabolic models, to optimize CHO cell…
October 24, 2018
…Medicine researchers hope to create a high resolution reference map of pancreatic cells that will identify molecular changes that arise during type 1 diabetes.
October 16, 2012
Bioengineers at the University of California, San Diego have received a $9.3 million grant from the National Institutes of Health to establish a single-cell genomics center and develop a three-dimensional map of gene activities in individual cells in the human cortex.
August 13, 2019
UC San Diego School of Medicine has been awarded $9 million to fund research projects using human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes aimed at identifying the cellular actions leading to disease onset.
