March 25, 2013
Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells.
September 15, 2014
During cancer development, tumor cells decorate their surfaces with sugar compounds called glycans that are different from those found on normal, healthy cells. Researchers at the University of California, San Diego School of Medicine report that sialic acids at the tips of these cancer cell glycans are capable of engaging…
June 22, 2020
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
November 21, 2017
…environment surrounding a tumor can trigger metastatic behavior in cancer cells. Specifically, when tumor cells are confined in a dense environment, the researchers found that they turn on a specific set of genes and begin to form structures that resemble blood vessels.
April 4, 2019
An international team of scientists led by researchers at University of California San Diego School of Medicine employed an array of next-generation sequencing and gene-editing tools, such as CRISPR, to map the molecular dependencies – and thus vulnerabilities – of pancreatic cancer stem cells.
April 3, 2014
Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation.
September 19, 2022
UC San Diego Health now offers a novel therapy option shown to extend the lifespan and improve quality of life for certain patients.
August 10, 2023
Creating new technologically advanced sensors, scientists from UC San Diego and Australia have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.
September 27, 2012
…grant by the National Cancer Institute, part of the National Institutes of Health. The grant is the second renewal of funding for a broad-based effort designed to better understand the pathology of CLL – the most common form of leukemia in the Western world – and develop new drugs and…
December 1, 2017
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.
