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Your search for “Cancer Mutations” returned 220 results

MicroRNA Specifically Kills Cancer Cells with Common Mutation

October 2, 2016

…percent of all human cancers have mutations in a gene called KRAS. KRAS-mutant cancers are among the most difficult to treat, with poor survival and resistance to chemotherapy. Researchers at University of California San Diego School of Medicine and Moores Cancer Center used microRNAs to systematically inhibit thousands of other…

Tumor Suppressor Mutations Alone Don’t Explain Deadly Cancer

August 3, 2014

Although mutations in a gene dubbed “the guardian of the genome” are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large…

Researchers Develop New Strategy to Target KRAS Mutant Cancer

September 13, 2017

In a new study, published this month in Cancer Discovery, University of California San Diego School of Medicine researchers report that approximately half of lung and pancreatic cancers that originate with a KRAS mutation become addicted to the gene as they progress.

A New Way to Target Cancers Using ‘Synthetic Lethality’

July 27, 2020

Researchers at Ludwig Institute for Cancer Research and University of California San Diego School of Medicine report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth.

Gene Mutation “Hotspots” Linked to Better Breast Cancer Outcomes

June 30, 2016

…of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer — patients with kataegis have less invasive tumors and better prognoses. The study, published June 30 in Cell Reports, also suggests kataegis status could help doctors determine treatment options that…

Topography of the Genome Influences Where Cancer Mutations Thrive, Study Shows

August 24, 2023

Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. Certain regions of the genome, which exhibit unique features, act as hotspots for the accumulation of mutations.

Mutational Signature Linking Bladder Cancer and Tobacco Smoking Found With New AI Tool

September 26, 2022

UC San Diego researchers have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. The work could help identify what environmental factors, such as exposure to tobacco smoke and UV radiation, cause cancer in certain patients.

Tethering of Shattered Chromosomal Fragments Paves Way for New Cancer Therapies

June 15, 2023

UC San Diego scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations

Clinical Study Suggests the Origin of Glioblastoma Subtypes

May 4, 2016

…types of glioblastoma, the most common form of brain cancer in adults, tend to develop in different regions of the brain. This finding provides an explanation for how the same cancer-causing mutation can give rise to different types of brain malignancies.

Mapping Mutation ‘Hotspots’ in Cancer Reveals New Drivers and Biomarkers

February 9, 2022

UC San Diego researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome. These mutation clusters contribute to the progression of about 10% of human cancers and can be used to predict patient survival.

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