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Your search for “CIRM” returned 69 results

Human Stem Cell Model Reveals Molecular Cues Critical to Neurovascular Unit Formation

May 21, 2015

Using human embryonic stem cells, researchers at University of California, San Diego School of Medicine and Moores Cancer Center and Sanford-Burnham Medical Research Institute created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time,…

Binding Sites for LIN28 Protein Found in Thousands of Human Genes

September 4, 2012

…Institute for Regenerative Medicine (CIRM) looks at an important RNA binding protein called LIN28, which is implicated in pluripotency and reprogramming as well as in cancer and other diseases. According to the researchers, their study – published in the September 6 online issue of Molecular Cell – will change how…

Drug Targets Hard-to-Reach Leukemia Stem Cells Responsible for Relapses

January 17, 2013

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – and thus vulnerable – to a novel cancer stem cell-targeting drug currently under development.

Body’s Own Gene Editing System Generates Leukemia Stem Cells

June 9, 2016

Cancer stem cells are like zombies — even after a tumor is destroyed, they can keep coming back. These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors. Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic…

Stem Cell-Based Phase I Trial to Repair Spinal Cord Injuries Produces Encouraging Results

June 1, 2018

Researchers at University of California San Diego School of Medicine report that a first-in-human phase I clinical trial in which neural stem cells were transplanted into participants with chronic spinal cord injuries produced measurable improvement in three of four subjects, with no serious adverse effects.

$100 Million Gift Launches Sanford Stem Cell Clinical Center

November 4, 2013

…Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, has awarded UC San Diego scientists more than 60 grants totaling almost $138 million, with millions more given to other area institutions. Lawrence Goldstein, PhD, professor in the Departments of Cellular and Molecular Medicine and Neurosciences, director of the UC…

UC San Diego Human Milk Institute Names its Executive Director

October 2, 2023

UC San Diego Human Milk Institute names Mitra Hooshmand, PhD, as its Executive Director. Hooshman will lead strategy and operations at the innovative research institute.

Enzyme Accelerates Malignant Stem Cell Cloning in Chronic Myeloid Leukemia

January 2, 2013

An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is…

UC San Diego Sends Blood Stem Cells to Space

December 21, 2021

Researchers at the University of California San Diego launched blood stem cells into space aboard a SpaceX Falcon 9 rocket to study stress-induced aging and how stem cells and their progeny transform into pre-cancer and cancer stem cells associated with leukemia and other blood cancers.

Study Identifies Cause for Excessive Folding of Gyri in Human Cerebral Cortex

January 18, 2023

UC San Diego researchers identify mutation that causes excessive folding in human brain’s wrinkly cerebral cortex, resulting in diminished cognitive function.

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