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Your search for “CIRM” returned 65 results

Drug Targets Hard-to-Reach Leukemia Stem Cells Responsible for Relapses

January 17, 2013

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – and thus vulnerable – to a novel cancer stem cell-targeting drug currently under development.

Body’s Own Gene Editing System Generates Leukemia Stem Cells

June 9, 2016

Cancer stem cells are like zombies — even after a tumor is destroyed, they can keep coming back. These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors. Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic…

Stem Cell-Based Phase I Trial to Repair Spinal Cord Injuries Produces Encouraging Results

June 1, 2018

Researchers at University of California San Diego School of Medicine report that a first-in-human phase I clinical trial in which neural stem cells were transplanted into participants with chronic spinal cord injuries produced measurable improvement in three of four subjects, with no serious adverse effects.

$100 Million Gift Launches Sanford Stem Cell Clinical Center

November 4, 2013

…Institute for Regenerative Medicine (CIRM), the state’s stem cell agency, has awarded UC San Diego scientists more than 60 grants totaling almost $138 million, with millions more given to other area institutions. Lawrence Goldstein, PhD, professor in the Departments of Cellular and Molecular Medicine and Neurosciences, director of the UC…

UC San Diego Human Milk Institute Names its Executive Director

October 2, 2023

UC San Diego Human Milk Institute names Mitra Hooshmand, PhD, as its Executive Director. Hooshman will lead strategy and operations at the innovative research institute.

Enzyme Accelerates Malignant Stem Cell Cloning in Chronic Myeloid Leukemia

January 2, 2013

An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is…

UC San Diego Sends Blood Stem Cells to Space

December 21, 2021

Researchers at the University of California San Diego launched blood stem cells into space aboard a SpaceX Falcon 9 rocket to study stress-induced aging and how stem cells and their progeny transform into pre-cancer and cancer stem cells associated with leukemia and other blood cancers.

Study Identifies Cause for Excessive Folding of Gyri in Human Cerebral Cortex

January 18, 2023

UC San Diego researchers identify mutation that causes excessive folding in human brain’s wrinkly cerebral cortex, resulting in diminished cognitive function.

Computational Modeling Results in New Findings for Preeclampsia Patients

July 12, 2021

According to the Centers for Disease Control and Prevention, preeclampsia, or pregnancy-related hypertension, occurs in roughly one in 25 pregnancies in the United States. The causes are unknown and childbirth is the only remedy, which can sometimes lead to adverse perinatal outcomes

Two Anti-viral Enzymes Transform Pre-Leukemia Stem Cells into Leukemia

January 26, 2021

Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth.

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