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Your search for “Neurodegeneration” returned 156 results

Multiple Pathways Progressing to Alzheimer’s Disease

June 25, 2015

UC San Diego School of Medicine researchers report that the amyloid cascade hypothesis, long believed to describe the pathology of Alzheimer’s disease, is not a fixed and invariable sequence of events. Rather, early indicators or biomarkers of the neurodegenerative condition vary by individual, making preclinical diagnoses more challenging.

Eyes Provide Peek at Alzheimer’s Disease Risk

August 23, 2021

Amyloid plaques found in the retinas of eyes may be an indicator of similar plaques in the brain, a hallmark of Alzheimer’s disease, and may provide a more visible biomarker for detecting disease risk.

Intermittent Fasting Improves Alzheimer’s Pathology

August 21, 2023

New results from researchers at UC San Diego School of Medicine suggest that intermittent fasting could be an effective treatment approach for Alzheimer’s disease. Mice fed on a time-restricted schedule had better memory and less accumulation of amyloid proteins in the brain compared to controls.

Two Proteins Offer a “Clearer” Way to Treat Huntington’s Disease

July 11, 2012

In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of Huntington’s disease (HD).

Researchers Identify Key Mechanisms Underlying HIV-Associated Cognitive Disorders

February 3, 2015

New findings by researchers at the University of California, San Diego School of Medicine open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders (HAND), estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.

Nanoparticles Detect Biochemistry of Inflammation

September 18, 2012

Adah Almutairi, associate professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences, the department of nanoengineering, and the materials science and engineering program at the UC San Diego, and colleagues have developed the first degradable polymer that is extremely sensitive to low but biologically relevant concentrations of hydrogen peroxide.

Gene Therapy in Alzheimer’s Disease Mouse Model Preserves Learning and Memory

May 4, 2021

Researchers at UC San Diego have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer’s disease, a key step toward eventually testing the approach in humans with the neurodegenerative disease.

Plaque Deposits Alone Do Not Trigger Clinical Symptoms of Alzheimer’s, Researchers Find

April 23, 2012

According to a new study, the neuron-killing pathology of Alzheimer’s disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau.

Dysfunctional Endosomes are Early Sign of Neurodegeneration

April 11, 2016

Writing in the April 11 issue of The Journal of Clinical Investigation, researchers at University of California, San Diego School of Medicine say abnormalities in a protein that helps transport and sort materials inside cells are linked to axonal dysfunction and degeneration of neurons in Alzheimer’s disease (AD) and Down…

Potential Nutritional Therapy for Childhood Neurodegenerative Disease

August 1, 2013

…particularly severe form of pontocerebellar hypoplasia, a currently incurable neurodegenerative disease affecting children. Based on results in cultured cells, they are hopeful that a nutritional supplement may one day be able to prevent or reverse the condition.

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