November 3, 2016
November 3, 2016 —
By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes.
September 12, 2013
September 12, 2013 —
Researchers at the Pediatric Diabetes Research Center (PDRC) at the University of California, San Diego School of Medicine have shown that the pancreatic protein Nkx6.1 – a beta-cell enriched transcription factor – is essential to maintaining the functional state of beta cells.
January 12, 2021
January 12, 2021 —
Researchers at UC San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites — small molecules produced by the process of metabolism — may be predictive indicators for persons at risk for recurrent major depressive disorder.
September 11, 2019
September 11, 2019 —
An international team of researchers has discovered a cause for a rare eye disease affecting the macula that leads to loss of central vision, called macular telangiectasia type 2 (MacTel).
May 18, 2023
May 18, 2023 —
Researchers at the University of California San Diego have identified the conditions for cell metabolism to emerge on the early Earth, shedding new light on the origins of life itself, along with the fundamental nature of biological carbon fixation.
August 12, 2020
August 12, 2020 —
The enzyme serine palmitoyl-transferase can be used as a metabolically responsive “switch” that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature.
January 14, 2025
January 14, 2025 —
…out a gene circuit responsible for producing lactic acid—a metabolite that makes the cells’ environment toxic—researchers eliminate a primary hurdle in developing cells that can produce higher amounts of pharmaceuticals like Herceptin and Rituximab, without compromising their growth or energy production.
October 7, 2014
October 7, 2014 —
Researchers at the University of California, San Diego School of Medicine have identified a microRNA molecule as a surprisingly crucial player in managing cell survival and growth. The findings underscore the emerging recognition that non-coding RNAs help regulate basic cellular processes and may be key to developing new drugs and…
August 30, 2012
August 30, 2012 —
Open an undergraduate biochemistry textbook and you will learn that enzymes are highly efficient and specific in catalyzing chemical reactions in living organisms, and that they evolved to this state from their “sloppy” and “promiscuous” ancestors to allow cells to grow more efficiently.
September 9, 2014
September 9, 2014 —
Researchers at the University of California, San Diego School of Medicine, in partnership with ViaCyte, Inc., a San Diego-based biotechnology firm specializing in regenerative medicine, have launched the first-ever human Phase I/II clinical trial of a stem cell-derived therapy for patients with Type 1 diabetes.