December 10, 2020
…effective in patients with melanoma and head and neck cancers. After seeing that Thurman’s cancer was unabated on the immunotherapy trial, he was enrolled as the first patient and received a personalized TIL therapy on Tuesday. “Treating our first patient with his own cells generated at UC San Diego marks…
April 27, 2022
The cowpea mosaic virus has shown great promise as an experimental cancer immunotherapy for treating and preventing recurrence of various cancers. But just how the virus triggers such a potent anti-cancer immune response has remained a mystery. A new study digs deeper and provides answers.
August 22, 2018
In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain and Finland, describe for the first time how one type of RNA polymerase gets stalled by DNA lesions caused by exposure to ultraviolet (UV) light.
October 18, 2023
UC San Diego engineers have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. Its success lies in targeting a protein known to play a central role in cancer growth and spread, rather than targeting the primary tumor itself.
January 23, 2014
A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling…
October 15, 2019
UC San Diego bioengineers are a step closer to making CAR T-cell therapy safer, more precise and easy to control. They developed a system that allows them to select where and when CAR T cells get turned on so that they destroy cancer cells without harming normal cells.
June 26, 2015
Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.
March 7, 2017
Honjo received the 2016 Kyoto Prize—Japan’s highest private award for global achievement—in the area of “Basic Sciences” for his contributions to medical science. His work has been described as initiating a historic turning point—a “penicillin moment”—in the fight against cancer.
April 19, 2017
Rock star drummer Rikki Rockett feels very lucky to be on tour with his band, Poison. A year ago, he didn’t know if he would survive tongue cancer but after participating in an immunotherapy clinical trial at Moores Cancer Center at UC San Diego Health, he was declared cancer-free in…
June 22, 2020
UC San Diego researchers uncovered in mice how IRE1α, a molecule involved in cells’ response to stress, determines whether macrophages promote inflammation in the tumor microenvironment. Inflammation is known to promote tumor growth, making IRE1α an attractive target for drug development.
